ABC Laboratories provides GLP and non-GLP services for preclinical in-vitro and in-vivo programs. Our drug metabolism and pharmacokinetics experts reliably quantify and interpret results to put IND-enabling programs on the fast track. ABC's unique combination of radio-labeling expertise, in-vitro DMPK study design and execution, and a partnership with a leading cellular/subcellular service provider enables us to streamline preclinical programs, expediting the path to first-in-human studies.
Metabolic Stability
- Interspecies Comparisons
- Metabolism (S9, Microsomal, Hepatocytes)
- Metabolite Profiling and Identification (Proposed Metabolic Pathway)
Cytochrome P450 Inhibition
- IC50 and Ki Determinations
- Mechanism-based Inhibition
- Validated LC-MS/MS Methods
Cytochrome P450 Induction (ex-vivo and in-vitro)
- LC-MS/MS Method for P450 Activity
Cytochrome P450 Reaction Phenotyping
- Correlation Analysis
- Chemical/Antibody Inhibition
- cDNA Expressed Enzymes
Drug-Drug Interactions
- In-vitro evaluation of drug-drug interactions
- Analytical Method Development (HPLC or LC-MS/MS)
Protein Binding (in-vitro and in-vivo samples)
- Equilibrium Dialysis
- Ultrafiltration
- Ultracentrifugation
Data Acquisition/Reporting
- Analyst
- Win NonLin
- Sigmastat
- Empower 2
- Daily backup of raw data
- Detailed, customized reports & electronic reporting available