Radiolabeling demands extensive training, experience, and an understanding of where on a molecule a label should be introduced to optimize stability and cost-efficiency. ABC Laboratories maintains a staff of talented, Ph.D.-level radiosynthetic chemists who are known for their ability to introduce radioactive and stable isotope labels at positions optimal for supporting in-vitro and in-vivo DMPK studies.
Our synthesis group supports our DMPK/Bioanalytical and CGMP analytical groups with research-grade and GLP materials—including APIs, internal and reference standards, intermediates and other materials used for impurity and metabolite identification.
Preclinical Support
- Radiolabled (14C) API for in-vivo and in-vitro studies
- API (tox lot) suitable for preclinical GLP studies
- Reference standard synthesis and qualification
- Stable-labeled API/metabolites (13C or 2H) for use as internal standard
- Impurity identification, isolation, synthesis and characterization
- Analytical support dedicated to synthesis activities